Fork-head box protein A1 (FOXA1) is a "pioneer factor" that is known to bind to the androgen receptor (AR) and regulate the transcription of AR-specific genes.However, the precise role of FOXA1 in prostate cancer (PC) remains unknown.In this study, we report that FOXA1 plays a critical role in PC cell proliferation.The expression of FOXA1 was highe
Metabolic and Population Effects of Winter Tick Infestations on Moose: Unique Evolutionary Circumstances?
Moose (Alces alces) have evolved to store adequate body fat to emerge from winter in adequate nutritional condition that is key to annual productivity and neonatal survival.Blood consumption by winter ticks (Dermacentor albipictus) affects survival and productivity of moose, often resulting in marked local and regional die-offs of calves.Concurrent
The Role of a Smart Health Ecosystem in Transforming the Management of Chronic Health Conditions
The effective management of chronic conditions requires an approach that promotes a shift in care from the clinic to the home, improves the efficiency of health care systems, and benefits all users irrespective of their needs and preferences.Digital health can provide a solution to this challenge, and in this paper, we provide our vision for a smar
Evaluating the Influence of Water Scarcity on the Host Response of Garlic to the Stem and Bulb Nematode Ditylenchus dipsaci
Ditylenchus dipsaci is a plant-parasitic nematode with Ballpoint Pen a great economic impact on bulbous crops, including garlic (Allium sativum L.), and is distributed worldwide, particularly in the Mediterranean region.Traditionally, garlic was a rainfed crop in Spain, but irrigated areas have increased during the last few decades.However, the exp